
Spears has performed the song in a number of live appearances including the 2003 NFL Kickoff Live, Saturday Night Live, 2003 American Music Awards and TRL. The video received positive reviews from critics, who noted it as symbolic of the sexual roles between the women.

A cat-and-mouse chase ensues, and Spears finds Madonna in the end, only for the latter to disappear before they kiss. The accompanying music video for "Me Against the Music" shows Spears and Madonna playing opposites in a nightclub. The song won the "Hot Dance Single of the Year" accolade at the 2004 Billboard Music Awards. It also peaked at number two in Canada, Italy, Norway and the United Kingdom, and inside the top five in many other nations. The song was a commercial success, peaking atop of the charts in countries such as Australia, Denmark, Hungary, Ireland and Spain, as well as the European Hot 100 Singles. Some felt it was a strong dance track of In the Zone, while others referred to it as lackluster and disappointing. The song received generally mixed reviews from music critics. Lyrically, the song talks about battling the music and the pleasures of letting go on the dancefloor. Spears and Madonna trade lines during the verses, and Madonna sings the bridge. "Me Against the Music" contains influences of dance-pop, hip hop and usage of funk guitars. During rehearsals for the 2003 MTV Video Music Awards, Spears played Madonna the track and asked her to do the song with her.

After bonding with Spears during a night in New York City, Stewart and Magnet started working on the song for her. The song was released on October 14, 2003, by Jive Records, as the lead single of In the Zone.

It was written by Spears, Madonna, Christopher "Tricky" Stewart, Thabiso "Tab" Nikhereanye, Penelope Magnet, Terius Nash and Gary O'Brien. " Me Against the Music" is a song by American singers Britney Spears and Madonna for Spears' fourth studio album, In the Zone (2003).
